What is Ozone Major Autohemotherapy (HBO3)?

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Ozone major autohemotherapy (10-pass method) therapy, also known as hyperbaric ozone major autohemotherapy, is the safest and gentlest method of administering ozone for the treatment of many different types of diseases, including infections, cardiovascular, mitochondrial and inflammatory diseases. When properly administered, ozone therapy can be radically transformative to regulate inflammation and stimulate tissue regeneration in autoimmune diseases, cancer, and a wide range of other diseases.

To put it simply, the goal of ozone therapy is to trigger your body to improve mitochondrial energy production, regenerate connective tissue, modify inflammation epigenetically, and improve autonomic nervous system balance. 

Ozone major autohemotherapy is a globally recognized method for stimulating tissue repair and increasing cellular energy production. Most importantly, our success is based on both clinical experience worldwide and a robust scientific understanding with a rapidly growing body of scientific literature. Read more below to learn how ozone works, how our therapy works, and how to get started.


Our office is equipped with the most recent medical device breakthrough in ozone therapy from Germany, the Herrman Apparatebau Medozone. Each session ranges from 20-120 mins depending on the extent of treatment. During this time, a small portion of your body's blood supply (typically 250mL) is removed from a vein in the patient's arm and briefly stored in an airtight oxygen/ozone environment. As soon as enough blood has been removed, the blood is then re-infused through the same vein while being mixed with oxygen/ozone, all the while kept in motion in an oxygen rich environment. Each time this is performed is referred to as a "pass." 

Depending on the disease being treated and the general state of the patient, the procedure may be performed from 1 to 10 times, aka "passes." With each "pass," 200-250mL of the patient's blood is ozonated at a specific concentration triggering a cascade effect that can produce a sense of relaxation and wellbeing even during the therapy. Afterwards, the patient is instructed to keep the area bandaged for up to 6 hours because of the required administration of a blood thinner (heparin) to prevent coagulation during the therapy. 

Afterwards, patients may feel immediately energized or may become very sleepy. It is important to let the body rest if tired, as ozone therapy is triggering the body to heal itself - and the repairs generally happen while asleep. The therapy may be repeated up to 3 times per week in some severe cases of cancer and cardiovascular disease, but is generally recommended 1-2 times per week, for a predetermined interval of time based on your response after the first "trial" session. Eventually the goal of therapy includes extending the amount of time in between sessions to required to maintain the benefit. Since ozone major autohemotherapy mimics many of the benefits of exercise, a regular vigorous exercise program may be all that is needed to maintain the benefits of treatment.


Prior to each treatment, it is important to be well hydrated and to have preferably eaten a moderately sized meal 1-2 hours before. If you can do some sort of cardiovascular exercise the day of or the day prior to this therapy it will generally speed up the time it takes.


For the first session, the patient is booked for a 60min appointment. During this time an interview is conducted and the informed consent is reviewed. Any questions can be addressed at length prior to the treatment. Following the interview, the ozone major autohemotherapy is performed with 1-4 passes, depending on the state of the patient and speed of the procedure. The patient is then asked to schedule a free, brief phone consult afterwards (2-7 days afterwards) to determine the response to therapy 2-3 days afterwards. During this follow up phone call a more clear estimate of the extent of treatment and the recommended frequency can be established (based on the patient's response).


After the first session a follow up treatment is typically recommended. It may be either a 1-hour or 2-hour session. The amount of passes that can be performed depends on the speed and efficiency of treatment. 

  • Sessions are typically $350 for multiple passes, based on time spent with the doctor as well as other factors such as frequency of therapy as part of a broader treatment plan.

Please continue reading below for more specifics on what diseases can be treated and how ozone works.


Our device: The Herrman Apparatebau Medozone


Ozone major autohemotherapy is a treatment for fatigue, cardiovascular diseases, chronic infections, certain types of cancer, autoimmune diseases, geriatric and many other illnesses. Ozone triggers the blood to release certain chemical messengers that communicate with the rest of the body to produce a series of effects including regeneration of tissues and increased oxygen metabolism throughout the body. Please see this 2011 scientific article briefly discussing the clinical uses of ozone worldwide. (Download article here



  • upregulates the body’s detoxification systems (phase I and II)

  • causes a rapid reduction in inflammation

  • increasee efficiency of oxygen metabolism

  • produces new blood vessels

  • initiates tissue regeneration

  • increases antioxidant capacity

  • stimulates detoxification

Ozone major autohemotherapy triggers many changes in the body. These include: decrease in inflammation, increase in mitochondrial function, increase in detoxification pathways, increase in antioxidant production, stimulation of repair of damaged proteins and DNA, release of growth factors, opening of blood vessels improving oxygenation of tissues, increase in neurotransmitter production, stimulation of neuroprotective mechanisms and many more... Read below to learn more specifics.

Through a mild oxidative stress, ozone stimulates the body to release an anti-inflammatory molecule called NRF2. Once released, NRF2 binds to the DNA causing the production of antioxidant response elements, thereby upregulating the body’s natural antioxidant and detoxification system. At the same time, ozone is inhibiting NFkB causing a rapid reduction in inflammation in the body. An extensive scientific review of how ozone works can be found at the following link: (Download this article here): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298518/

Ozone is also responsible for activating hypoxia inducible factor-1alpha, which causes another cascade of effects resulting in increased efficiency of oxygen metabolism and production of new blood vessel formation. The net result is an increase in TGFB-1 and 4-HNE, producing tissue regeneration, a further increase in antioxidant capacity, and stimulation of detoxification pathways. Read more from another article here: (Download the article here). https://medicalgasresearch.biomedcentral.com/articles/10.1186/2045-9912-1-6

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